Epigenetic modifications may serve as indicators of past toxic exposures and predict future disease risk. We propose to discover and validate novel methylomic biomarkers of air pollution exposure and related phenotypic outcomes of interest. Our understanding about the complex interplay of epigene-environment interactions remains rudimentary, and it often based on high-exposure animal models. This array-based methylomics study employs the Normative Aging Study (NAS) cohort, followed for over 40+ years, to identify key epigenetic pathways in humans; the Illumina HumanMethylation450 BeadChip was used to query the methylation status of ~480K CpG sites across the human genome. These epigenetic marks may aid in the early diagnosis and prevention of air pollution-related diseases and the study of basic biological processes in vivo.
Carmona, J., Barfield, R., Just, A., Colicino, E., Testa, P., Pafundi, P., et al. (2013). DNA methylation signatures in the Normative Aging Study:Epigenome-wide association analyses of air pollution exposure,biological aging, metabolism, and lung function decline. Intervento presentato a: PQG Conference 2013, Harvard School of Public Health, Boston, MA.
DNA methylation signatures in the Normative Aging Study:Epigenome-wide association analyses of air pollution exposure,biological aging, metabolism, and lung function decline
PAFUNDI, PIA CLARA;
2013
Abstract
Epigenetic modifications may serve as indicators of past toxic exposures and predict future disease risk. We propose to discover and validate novel methylomic biomarkers of air pollution exposure and related phenotypic outcomes of interest. Our understanding about the complex interplay of epigene-environment interactions remains rudimentary, and it often based on high-exposure animal models. This array-based methylomics study employs the Normative Aging Study (NAS) cohort, followed for over 40+ years, to identify key epigenetic pathways in humans; the Illumina HumanMethylation450 BeadChip was used to query the methylation status of ~480K CpG sites across the human genome. These epigenetic marks may aid in the early diagnosis and prevention of air pollution-related diseases and the study of basic biological processes in vivo.
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