Carbohydrates play dynamic structural and biochemical key roles in complex biological systems. Their natural functions represent a continuing source of inspiration for the generation of artificial tools for biomedical applications, including tissue engineering. Polysaccharides are extensively employed in the development of permanent, semipermanent, and biodegradable medical devices thanks to their structural or biochemical properties. Oligosaccharides and small glycidic epitopes are revealing impressive functional cell-extracellular matrix (ECM) crosstalk, inducing tissue morphogenesis and pathological events. Here in this chapter, the major applications of carbohydrates in medical devices and regenerative medicine are reported, including the implications related to glycans’ recognition in xenotransplants.
Russo, L., Nicotra, F. (2023). Carbohydrates in Tissue Engineering. In R. Adamo, L. Lay (a cura di), Carbohydrate‐Based Therapeutics (pp. 223-243). Hoboken : Wiley-VCH GmbH [10.1002/9783527831326.ch8].
Carbohydrates in Tissue Engineering
Russo L.;Nicotra F.
2023
Abstract
Carbohydrates play dynamic structural and biochemical key roles in complex biological systems. Their natural functions represent a continuing source of inspiration for the generation of artificial tools for biomedical applications, including tissue engineering. Polysaccharides are extensively employed in the development of permanent, semipermanent, and biodegradable medical devices thanks to their structural or biochemical properties. Oligosaccharides and small glycidic epitopes are revealing impressive functional cell-extracellular matrix (ECM) crosstalk, inducing tissue morphogenesis and pathological events. Here in this chapter, the major applications of carbohydrates in medical devices and regenerative medicine are reported, including the implications related to glycans’ recognition in xenotransplants.
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