Autoimmune liver diseases (AILDs) have an important genetic background. This is supported by different lines of evidence, that is, clustering in families, high concordance rates in monozygotic twins, increased risk of the disease in siblings compared to general population, and association with other autoimmune conditions. In this chapter, we summarize current knowledge regarding each of the three most common AILDs (autoimmune hepatitis, AIH; primary biliary cholangitis, PBC; and primary sclerosing cholangitis, PSC); we then propose a series of possible future lines of investigation to explore the amount of heritability, which is still to be determined.
Gerussi, A., Carbone, M., Asselta, R., Invernizzi, P. (2020). Genetics of Autoimmune Liver Diseases. In E.M. Gershwin, J.M. Vierling, A. Tanaka, M.P. Manns (a cura di), Liver Immunology: Principles and Practice (pp. 69-85). Springer International Publishing [10.1007/978-3-030-51709-0_5].
Genetics of Autoimmune Liver Diseases
Gerussi A.;Carbone M.;Invernizzi P.
2020
Abstract
Autoimmune liver diseases (AILDs) have an important genetic background. This is supported by different lines of evidence, that is, clustering in families, high concordance rates in monozygotic twins, increased risk of the disease in siblings compared to general population, and association with other autoimmune conditions. In this chapter, we summarize current knowledge regarding each of the three most common AILDs (autoimmune hepatitis, AIH; primary biliary cholangitis, PBC; and primary sclerosing cholangitis, PSC); we then propose a series of possible future lines of investigation to explore the amount of heritability, which is still to be determined.
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