Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) has revolutionized the complex scientific field of disease modelling and personalized therapy. Cardiac differentiation of human iPSCs into cardiomyocytes (hiPSC-CMs) has been used in a wide range of healthy and disease models by deriving CMs from different somatic cells. Unfortunately, hiPSC-CMs have to be improved because existing protocols are not completely able to obtain mature CMs recapitulating physiological properties of human adult cardiac cells. Therefore, improvements and advances able to standardize differentiation conditions are needed. Lately, evidences of an epigenetic memory retained by the somatic cells used for deriving hiPSC-CMs has led to evaluation of different somatic sources in order to obtain more mature hiPSC-derived CMs.

Lodrini, A., Barile, L., Rocchetti, M., Altomare, C. (2020). Human induced pluripotent stem cells derived from a cardiac somatic source: insights for an in-vitro cardiomyocyte platform. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(2) [10.3390/ijms21020507].

Human induced pluripotent stem cells derived from a cardiac somatic source: insights for an in-vitro cardiomyocyte platform

Lodrini A. M.
Primo
;
Rocchetti M.
Penultimo
;
Altomare C.
Ultimo
2020

Abstract

Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) has revolutionized the complex scientific field of disease modelling and personalized therapy. Cardiac differentiation of human iPSCs into cardiomyocytes (hiPSC-CMs) has been used in a wide range of healthy and disease models by deriving CMs from different somatic cells. Unfortunately, hiPSC-CMs have to be improved because existing protocols are not completely able to obtain mature CMs recapitulating physiological properties of human adult cardiac cells. Therefore, improvements and advances able to standardize differentiation conditions are needed. Lately, evidences of an epigenetic memory retained by the somatic cells used for deriving hiPSC-CMs has led to evaluation of different somatic sources in order to obtain more mature hiPSC-derived CMs.
Articolo in rivista - Review Essay
Cell modelling; Drug testing; Epigenetic memory; hiPSC-CMs; Maturation
English
13-gen-2020
2020
21
2
507
open
Lodrini, A., Barile, L., Rocchetti, M., Altomare, C. (2020). Human induced pluripotent stem cells derived from a cardiac somatic source: insights for an in-vitro cardiomyocyte platform. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(2) [10.3390/ijms21020507].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/282619
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