Understanding the synchronization, either induced or spontaneous, of cell growth, division and proliferation in a cell culture is an important topic in molecular biology and biotechnology. Metabolic processes related to the synthesis of all the molecules needed for a new round of cell division are the basic underlying phenomena responsible for the behaviour of the population. Complex dynamics, such as population oscillations, arise when the individual members of a population divide in unison. To investigate the conditions that can determine oscillatory behaviors, we here use a multi-scale model that couples the simulation of metabolic growth, via metabolic network modelling and Flux Balance Analysis, with the simulation of population and spatial dynamics, via Cellular Potts Models. We here show that repeated oscillations in the overall number of cells spontaneously emerge, due to the synchronization of duplication events, unless cell density-dependent controls on growth are introduced

Maspero, D., Graudenzi, A., AMARPAL SINGH, A., Pescini, D., Mauri, G., Antoniotti, M., et al. (2019). Synchronization effects in a metabolism-driven model of multi-cellular system. In 13th Italian Workshop, WIVACE 2018, Parma, Italy, September 10–12, 2018, Revised Selected Papers (pp.115-126) [10.1007/978-3-030-21733-4_9].

Synchronization effects in a metabolism-driven model of multi-cellular system

MASPERO, DAVIDE
Primo
;
Graudenzi, A
Secondo
;
AMARPAL SINGH, AASHRIT SINGH;Pescini, D;Mauri, G;Antoniotti, M
Penultimo
;
Damiani, C
Ultimo
2019

Abstract

Understanding the synchronization, either induced or spontaneous, of cell growth, division and proliferation in a cell culture is an important topic in molecular biology and biotechnology. Metabolic processes related to the synthesis of all the molecules needed for a new round of cell division are the basic underlying phenomena responsible for the behaviour of the population. Complex dynamics, such as population oscillations, arise when the individual members of a population divide in unison. To investigate the conditions that can determine oscillatory behaviors, we here use a multi-scale model that couples the simulation of metabolic growth, via metabolic network modelling and Flux Balance Analysis, with the simulation of population and spatial dynamics, via Cellular Potts Models. We here show that repeated oscillations in the overall number of cells spontaneously emerge, due to the synchronization of duplication events, unless cell density-dependent controls on growth are introduced
paper
Computational Biology; Metabolism
English
XIII Workshop on Artificial Life and Evolutionary Computation, WIVACE 2018
2018
Stefano Cagnoni, Monica Mordonini, Riccardo Pecori, Andrea Roli, Marco Villani
13th Italian Workshop, WIVACE 2018, Parma, Italy, September 10–12, 2018, Revised Selected Papers
978-3-030-21732-7
30-mag-2019
2019
900
115
126
https://link.springer.com/chapter/10.1007/978-3-030-21733-4_9
none
Maspero, D., Graudenzi, A., AMARPAL SINGH, A., Pescini, D., Mauri, G., Antoniotti, M., et al. (2019). Synchronization effects in a metabolism-driven model of multi-cellular system. In 13th Italian Workshop, WIVACE 2018, Parma, Italy, September 10–12, 2018, Revised Selected Papers (pp.115-126) [10.1007/978-3-030-21733-4_9].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/204168
Citazioni
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 1
Social impact