There is general agreement that type 2 diabetes is the consequence of insulin resistance, defined as an impaired ability of insulin to control hepatic and peripheral glucose metabolism, and of compromised pancreatic β-cell function such that insulin secretion is insufficient to compensate the degree of insulin resistance [1]. The pivotal role of insulin resistance is confirmed by the fact that it is a consistent finding in patients with type 2 diabetes. Indeed, insulin resistance may be detected 10-20 years before the onset of overt hyperglycemia and prospective studies have demonstrated that it is the best predictor of whether an individual will later become diabetic [2]
Perseghin, G. (2011). Excessive nutrients and regional energy metabolism. In Cellular Physiology and Metabolism of Physical Exercise (pp. 55-66). Springer-Verlag Italia s.r.l. [10.1007/978-88-470-2418-2_7].
Excessive nutrients and regional energy metabolism
PERSEGHIN, GIANLUCAPrimo
2011
Abstract
There is general agreement that type 2 diabetes is the consequence of insulin resistance, defined as an impaired ability of insulin to control hepatic and peripheral glucose metabolism, and of compromised pancreatic β-cell function such that insulin secretion is insufficient to compensate the degree of insulin resistance [1]. The pivotal role of insulin resistance is confirmed by the fact that it is a consistent finding in patients with type 2 diabetes. Indeed, insulin resistance may be detected 10-20 years before the onset of overt hyperglycemia and prospective studies have demonstrated that it is the best predictor of whether an individual will later become diabetic [2]
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