A decline in verbal fluency is the most consistent neuropsychological sequela of deep brain stimulation (DBS) for Parkinson's disease. We assessed clinical correlates and switching and clustering subcomponents in 26 parkinsonians undergoing subthalamic DBS. Post-surgical motor improvement was accompanied by worsening at both letter and category fluency tasks. Total number of words and switches decreased, while average cluster size was unchanged. Worsening tended to be prominent in patients with baseline poorer cognitive status and more depressed mood. Impairment of shifting suggests prefrontal dysfunction, possibly due to disruption of fronto-striatal circuits along the surgical trajectory and/or to high frequency stimulation itself.

De Gaspari, D., Siri, C., DI GIOIA, M., Antonini, A., Isella, V., Pizzolato, A., et al. (2006). Clinical correlates and cognitive underpinnings of verbal fluency impairment after chronic subthalamic stimulation in Parkinson's disease. PARKINSONISM & RELATED DISORDERS, 12(5), 289-295 [10.1016/j.parkreldis.2006.01.001].

Clinical correlates and cognitive underpinnings of verbal fluency impairment after chronic subthalamic stimulation in Parkinson's disease

DI GIOIA, MARCO;ISELLA, VALERIA;VERGANI, FRANCESCO;GAINI, SERGIO MARIA;APPOLLONIO, ILDEBRANDO;
2006

Abstract

A decline in verbal fluency is the most consistent neuropsychological sequela of deep brain stimulation (DBS) for Parkinson's disease. We assessed clinical correlates and switching and clustering subcomponents in 26 parkinsonians undergoing subthalamic DBS. Post-surgical motor improvement was accompanied by worsening at both letter and category fluency tasks. Total number of words and switches decreased, while average cluster size was unchanged. Worsening tended to be prominent in patients with baseline poorer cognitive status and more depressed mood. Impairment of shifting suggests prefrontal dysfunction, possibly due to disruption of fronto-striatal circuits along the surgical trajectory and/or to high frequency stimulation itself.
Articolo in rivista - Articolo scientifico
Parkinson's disease, deep brain stimulation, DBS, fluency, Clustering and switching; Verbal fluency; Aged; Basal Ganglia; Cluster Analysis; Cognition; Depression; Electrodes, Implanted; Female; Humans; Male; Middle Aged; Neural Pathways; Neurologic Examination; Neurosurgical Procedures; Speech Disorders; Subthalamus; Verbal Behavior; Aging; Neurology
English
2006
12
5
289
295
none
De Gaspari, D., Siri, C., DI GIOIA, M., Antonini, A., Isella, V., Pizzolato, A., et al. (2006). Clinical correlates and cognitive underpinnings of verbal fluency impairment after chronic subthalamic stimulation in Parkinson's disease. PARKINSONISM & RELATED DISORDERS, 12(5), 289-295 [10.1016/j.parkreldis.2006.01.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/937
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