Objective: To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy. Methods: Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system. Results: PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis. Conclusion: PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment
Galimberti, G., Conti, E., Zini, M., Piazza, F., Fenaroli, F., Isella, V., et al. (2008). Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?. CLINICAL BIOCHEMISTRY, 41(10-11), 914-916 [10.1016/j.clinbiochem.2008.03.015].
Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
Galimberti, G;Conti, E;Zini, M;Piazza, F;Isella, V;Facheris, M;Antolini, L;Ferrarese, C
2008
Abstract
Objective: To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy. Methods: Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system. Results: PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis. Conclusion: PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment
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