The efficacy of hybenx® oral tissue decontaminant for periodontal disease treatment: a case series study

The objective of this study was to evaluate the efficacy of a chemical device HYBENX® Oral Tissue Decontaminant in the treatment of chronic periodontitis in adult patients. With the aim to identify the antibacterial property of HYBENX®, two samples of periodontal pocket microbiota were collected by paper probes, at two different time points. T0 represents the first sampling performed before treatment while T1 represents the second time point, 15 days after HYBENX® treatment. A total of 11 patients were enrolled. For each patient, at each time point, two paper probes were collected. Polymerase Chain Reaction methodology was used to detect microbial activity. After the treatment, a remarkable decrease in bacteria amount was observed, both for total bacteria and some specific periodontal pathogens representing the red complex bacteria (i.e. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia). The average reduction was about 99% for each of the red complex bacteria and about 96% for total Bacteria. This decrease was highly statistically significant based on P-values. HYBENX® solution is an effective adjunct to eradicate bacterial loading in the pockets of patients affected by periodontitis. It is an efficacious medical device for use in the management of moderate to severe chronic periodontitis