Alzheimer's disease (AD) represents the most prevalent manifestation of the cognitive disorders in the elderly. The dramatic nature and the economic burden of the disease make AD a worl-wide problem. This paper reviews the genetic factors which explain the pathogenesis of AD, i.e., mutations of the genes encoding the amyloid precursor protein (APP), presenilin 1 (PS-1) and 2 (PS-2). Moreover, the polymorphism of the ApoE gene and the mutations of the hemochromatosis gene (HFE) are discussed. HFE mutations may anticipate the clinical manifestation of AD. The epigenetic factors related to AD are also discussed
Vergani, C., Sampietro, M., Caputo, L., Tagliabue, J., Casatta, A., Meregalli, M., et al. (2001). Cognitive disorders in the elderly. Genetic and epigenetic aspects. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 7, 429-434 [10.1016/S0167-4943(01)00170-4].
Cognitive disorders in the elderly. Genetic and epigenetic aspects
ANNONI, GIORGIO
2001
Abstract
Alzheimer's disease (AD) represents the most prevalent manifestation of the cognitive disorders in the elderly. The dramatic nature and the economic burden of the disease make AD a worl-wide problem. This paper reviews the genetic factors which explain the pathogenesis of AD, i.e., mutations of the genes encoding the amyloid precursor protein (APP), presenilin 1 (PS-1) and 2 (PS-2). Moreover, the polymorphism of the ApoE gene and the mutations of the hemochromatosis gene (HFE) are discussed. HFE mutations may anticipate the clinical manifestation of AD. The epigenetic factors related to AD are also discussed
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