We have characterized HLA antigens in subjects with beta-thalassaemia trait with and without iron overload. 50% of the cases with iron overload (v 18% of those without iron overload, P less than 0.01) are carriers of HLA-A3, the HLA antigen tightly linked to the IH allele. Thus, in a considerable number of these subjects, beta-thalassaemia and IH coexist. This association exerts a synergistic effect in inducing iron overload.
Fargion, S., Piperno, A., Panaiotopoulos, N., Taddei, M., Fiorelli, G. (1985). Iron overload in subjects with beta-thalassaemia trait: role of idiopathic haemochromatosis gene. BRITISH JOURNAL OF HAEMATOLOGY, 61(3), 487-490 [10.1111/j.1365-2141.1985.tb02852.x].
Iron overload in subjects with beta-thalassaemia trait: role of idiopathic haemochromatosis gene
PIPERNO, ALBERTOSecondo
;
1985
Abstract
We have characterized HLA antigens in subjects with beta-thalassaemia trait with and without iron overload. 50% of the cases with iron overload (v 18% of those without iron overload, P less than 0.01) are carriers of HLA-A3, the HLA antigen tightly linked to the IH allele. Thus, in a considerable number of these subjects, beta-thalassaemia and IH coexist. This association exerts a synergistic effect in inducing iron overload.
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