The synthesis and the use of the compounds with glycofused tricyclic structure as ligands of the Αβ peptides is the object of the invention. Such compounds result to be chemically stable, they have a high solubility under physiological conditions and they are suitable for functionalizations which make them easily conjugable to other entities to allow a therapeutic and diagnostic use thereof. The capability of the compounds to link the Αβ peptide, in the various shapes thereof, and in particular the most toxic one, represented by the oligomers, was evaluated through NMR experiments.(III)
Nicotra, F., Masserini, M., LA FERLA, B., Airoldi, C., Sironi, E., Cardona, F. (2011)New tricyclic compounds, process for their manufacture and their use as ligands of beta-alyloid peptides. . Brevetto No. IT2011RM00264 20110527.
New tricyclic compounds, process for their manufacture and their use as ligands of beta-alyloid peptides
NICOTRA, FRANCESCO;MASSERINI, MASSIMO ERNESTO;LA FERLA, BARBARA;AIROLDI, CRISTINA;
2011
Abstract
The synthesis and the use of the compounds with glycofused tricyclic structure as ligands of the Αβ peptides is the object of the invention. Such compounds result to be chemically stable, they have a high solubility under physiological conditions and they are suitable for functionalizations which make them easily conjugable to other entities to allow a therapeutic and diagnostic use thereof. The capability of the compounds to link the Αβ peptide, in the various shapes thereof, and in particular the most toxic one, represented by the oligomers, was evaluated through NMR experiments.(III)
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