Evaluation of the efficacy of a new natural gel in non-surgical periodontal therapy

OBJECTIVES The aim of this experimental in vi-vo research was to evaluate the efficacy of a new periodontal, top-ic and natural gel (mainly made by flowers and fruits sodium bicar-bonate and hyaluronic acid) as a substitute of Chlorexidine opera-tion, without the well-known side effects connected to her. The pri-mary hypothesis is to test that the new natural gel can reduce sig-nificantly Bleeding on Probing in-dex, Plaque index and Pocket depth index after non-surgical periodontal theraphy, if compared to Chlorexidine and a control group. MATERIALS AND METHODS 30 patients have been selected according to the following inclu-sion criteria: 18-70 years old, periodontal pockets greater then 3 mm, good compliance and col-laboration. The collected indexes were: Full Mouth Plaque Score, Full Mouth Bleeding Score and Probing Pocket Depth. 30 pa-tients have been divided into 3 groups: at T0 a collection of the indexes and a professional dental hygiene have been conducted for each group. At T1 group C patients (control group) had a Scaling and Roots planning treatment. Group A patients (Chlorexidine group) had both an SRP treatment and the administration of periodontal gel Curasept Chlorex-idine 1% (Curasept, Saronno-Varese, Italy) into pockets. Group B patients (natural gel group) had both an SRP treatment and the administration of periodontal gel Klirich Pro (Itena Clinical, Vil-lepinte, France) into pockets. Patients of groups A and B have been instructed to use their re-spective gel (Curasept gel 1% for group A and Klirich Home gel (Ite-na Clinical, Villepinte, France) for group B) in the following 10 days after the treatment. After 40 days (T2) a check has been carried out, in which we have collected indexes and eventually gel of group A and B have been admin-istered. Finally, 3 months after the check, indexes have been collected again and a professional dental hygiene has been conducted. RESULTS The Full Mouth Plaque Score reduction of each group is: group A 36%; Group B 41.3%; group C 12.9%. The greater reduction of FMPS is in group B, followed by group A. Group C shows a significant lower reduction of the index. Taking into consideration the Full Mouth Bleeding Score reduction: group A 34.2%; Group B 51%; Group C 19%. Even then, group A and B have a significant lower reduction if compared with group C. The median value of Probing Pocket Depth shows a reduction of 1.1 mm in group A and 0.9 in group B. Indeed, group C shows a reduction of 0.4 mm. CONCLUSIONS Statistical analysis demonstrates that the use of the natural gel, combined with non-surgical peri-odontal therapy, has a statistically significant role (P <0.05) in the in-dexes reduction. Within the limits of this research, because of the limited number of patients and the follow-up, we can conclude that this natural gel shows comparable results to the group treated with Chlorexidine gel, without showing side effect of pigmentation and dysgeusia. CLINICAL SIGNIFICANCE Results gained from this experimental study underline the grow-ing trend of using natural gel as an adjuvant of non-surgical periodontal therapy. Further studies should be conducted in order to confirm efficacy (taking into account FMPS, FMBS, PPD indexes) and to exclude potential side effects.