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Bicocca Open Archive
Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods: We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. Findings: Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer. Interpretation: As the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed. Funding: Bill & Melinda Gates Foundation.
Steinmetz, J., Seeher, K., Schiess, N., Nichols, E., Cao, B., Servili, C., et al. (2024). Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. LANCET NEUROLOGY, 23(4), 344-381 [10.1016/S1474-4422(24)00038-3].
Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Steinmetz J. D.;Seeher K. M.;Schiess N.;Nichols E.;Cao B.;Servili C.;Cavallera V.;Cousin E.;Hagins H.;Moberg M. E.;Mehlman M. L.;Abate Y. H.;Abbas J.;Abbasi M. A.;Abbasian M.;Abbastabar H.;Abdelmasseh M.;Abdollahi M.;Abdollahi M.;Abdollahifar M. -A.;Abd-Rabu R.;Abdulah D. M.;Abdullahi A.;Abedi A.;Abedi V.;Abeldano Zuniga R. A.;Abidi H.;Abiodun O.;Aboagye R. G.;Abolhassani H.;Aboyans V.;Abrha W. A.;Abualhasan A.;Abu-Gharbieh E.;Aburuz S.;Adamu L. H.;Addo I. Y.;Adebayo O. M.;Adekanmbi V.;Adekiya T. A.;Adikusuma W.;Adnani Q. E. S.;Adra S.;Afework T.;Afolabi A. A.;Afraz A.;Afzal S.;Aghamiri S.;Agodi A.;Agyemang-Duah W.;Ahinkorah B. O.;Ahmad A.;Ahmad D.;Ahmad S.;Ahmadzade A. M.;Ahmed A.;Ahmed A.;Ahmed H.;Ahmed J. Q.;Ahmed L. A.;Ahmed M. B.;Ahmed S. A.;Ajami M.;Aji B.;Ajumobi O.;Akade S.;Akbari M.;Akbarialiabad H.;Akhlaghi S.;Akinosoglou K.;Akinyemi R. O.;Akonde M.;Al Hasan S. M.;Alahdab F.;Al-Ahdal T. M. A.;Al-Amer R. M.;Albashtawy M.;AlBataineh M. T.;Aldawsari K. A.;Alemi H.;Alemi S.;Algammal A. M.;Al-Gheethi A. A. S.;Alhalaiqa F. A. N.;Alhassan R. K.;Ali A.;Ali E. A.;Ali L.;Ali M. U.;Ali M. M.;Ali R.;Ali S.;Shujait Ali S. S.;Ali Z.;Alif S. M.;Alimohamadi Y.;Aliyi A. A.;Aljofan M.;Aljunid S. M.;Alladi S.;Almazan J. U.;Almustanyir S.;Al-Omari B.;Alqahtani J. S.;Alqasmi I.;Alqutaibi A. Y.;Al-Shahi Salman R.;Altaany Z.;Al-Tawfiq J. A.;Altirkawi K. A.;Alvis-Guzman N.;Al-Worafi Y. M.;Aly H.;Aly S.;Alzoubi K. H.;Amani R.;Amindarolzarbi A.;Amiri S.;Amirzade-Iranaq M. H.;Amu H.;Amugsi D. A.;Amusa G. A.;Amzat J.;Ancuceanu R.;Anderlini D.;Anderson D. B.;Andrei C. L.;Androudi S.;Angappan D.;Angesom T. W.;Anil A.;Ansari-Moghaddam A.;Anwer R.;Arafat M.;Aravkin A. Y.;Areda D.;Ariffin H.;Arifin H.;Arkew M.;Arnlov J.;Arooj M.;Artamonov A. A.;Artanti K. D.;Aruleba R. T.;Asadi-Pooya A. A.;Asena T. F.;Asghari-Jafarabadi M.;Ashraf M.;Ashraf T.;Atalell K. A.;Athari S. S.;Atinafu B. T. T.;Atorkey P.;Atout M. M. W.;Atreya A.;Aujayeb A.;Avan A.;Ayala Quintanilla B. 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M.;Fornari A.;Foroutan B.;Fukumoto T.;Gadanya M. A.;Gaidhane A. M.;Galali Y.;Galehdar N.;Gan Q.;Gandhi A. P.;Ganesan B.;Gardner W. M.;Garg N.;Gau S. -Y.;Gautam R. K.;Gebre T.;Gebrehiwot M.;Gebremeskel G. G.;Gebreslassie H. G.;Getacher L.;Ghaderi Yazdi B.;Ghadirian F.;Ghaffarpasand F.;Ghanbari R.;Ghasemi M.;Ghazy R. M.;Ghimire S.;Gholami A.;Gholamrezanezhad A.;Ghotbi E.;Ghozy S.;Gialluisi A.;Gill P. S.;Glasstetter L. M.;Gnedovskaya E. V.;Golchin A.;Golechha M.;Goleij P.;Golinelli D.;Gomes-Neto M.;Goulart A. C.;Goyal A.;Gray R. J.;Grivna M.;Guadie H. A.;Guan B.;Guarducci G.;Guicciardi S.;Gunawardane D. A.;Guo H.;Gupta B.;Gupta R.;Gupta S.;Gupta V. B.;Gupta V. K.;Gutierrez R. A.;Habibzadeh F.;Hachinski V.;Haddadi R.;Hadei M.;Hadi N. R.;Haep N.;Haile T. G.;Haj-Mirzaian A.;Hall B. J.;Halwani R.;Hameed S.;Hamiduzzaman M.;Hammoud A.;Han H.;Hanifi N.;Hankey G. J.;Hannan M. A.;Hao J.;Harapan H.;Hareru H. E.;Hargono A.;Harlianto N. I.;Haro J. M.;Hartman N. N.;Hasaballah A. 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G.;Kadashetti V.;Kafi F.;Kalani R.;Kalantar F.;Kaliyadan F.;Kamath A.;Kamath S.;Kanchan T.;Kandel A.;Kandel H.;Kanmodi K. K.;Karajizadeh M.;Karami J.;Karanth S. D.;Karaye I. M.;Karch A.;Karimi A.;Karimi H.;Karimi Behnagh A.;Kasraei H.;Kassebaum N. J.;Kauppila J. H.;Kaur H.;Kaur N.;Kayode G. A.;Kazemi F.;Keikavoosi-Arani L.;Keller C.;Keykhaei M.;Khadembashiri M. A.;Khader Y. S.;Khafaie M. A.;Khajuria H.;Khalaji A.;Khamesipour F.;Khammarnia M.;Khan M.;Khan M. A. B.;Khan Y. H.;Suheb M. Z. K.;Khanmohammadi S.;Khanna T.;Khatab K.;Khatatbeh H.;Khatatbeh M. M.;Khateri S.;Khatib M. N.;Khayat Kashani H. R.;Khonji M. S.;Khorashadizadeh F.;Khormali M.;Khubchandani J.;Kian S.;Kim G.;Kim J.;Kim M. S.;Kim Y. J.;Kimokoti R. W.;Kisa A.;Kisa S.;Kivimaki M.;Kochhar S.;Kolahi A. -A.;Koly K. N.;Kompani F.;Koroshetz W. J.;Kosen S.;Kourosh Arami M.;Koyanagi A.;Kravchenko M. A.;Krishan K.;Krishnamoorthy V.;Defo B. K.;Kuddus M. A.;Kumar A.;Kumar G. A.;Kumar M.;Kumar N.;Kumsa N. B.;Kundu S.;Kurniasari M. D.;Kusuma D.;Kuttikkattu A.;Kyu H. H.;La Vecchia C.;Ladan M. A.;Lahariya C.;Laksono T.;Lal D. K.;Lallukka T.;Lam J.;Lami F. H.;Landires I.;Langguth B.;Lasrado S.;Latief K.;Latifinaibin K.;Lau K. M. -M.;Laurens M. B.;Lawal B. K.;Le L. K. D.;Le T. T. T.;Ledda C.;Lee M.;Lee S. -W.;Lee S. W.;Lee W. -C.;Lee Y. H.;Leonardi M.;Lerango T. L.;Li M. -C.;Li W.;Ligade V. S.;Lim S. S.;Linehan C.;Liu C.;Liu J.;Liu W.;Lo C. -H.;Lo W. D.;Lobo S. W.;Logroscino G.;Lopes G.;Lopukhov P. D.;Lorenzovici L.;Lorkowski S.;Loureiro J. A.;Lubinda J.;Lucchetti G.;Saute R. L.;Ma Z. F.;Mabrok M.;Machoy M.;Madadizadeh F.;El Razek M. M. A.;Maghazachi A. A.;Maghbouli N.;Mahjoub S.;Mahmoudi M.;Majeed A.;Malagon-Rojas J. N.;Malakan Rad E.;Malhotra K.;Malik A. A.;Malik I.;Mallhi T. H.;Malta D. C.;Manilal A.;Mansouri V.;Mansournia M. A.;Marasini B. P.;Marateb H. R.;Maroufi S. F.;Martinez-Raga J.;Martini S.;Martins-Melo F. R.;Martorell M.;Marz W.;Marzo R. R.;Massano J.;Mathangasinghe Y.;Mathews E.;Maude R. J.;Maugeri A.;Maulik P. K.;Mayeli M.;Mazaheri M.;McAlinden C.;McGrath J. J.;Meena J. K.;Mehndiratta M. M.;Mendez-Lopez M. A. M.;Mendoza W.;Mendoza-Cano O.;Menezes R. G.;Merati M.;Meretoja A.;Merkin A.;Mersha A. M.;Mestrovic T.;Mi T.;Miazgowski T.;Michalek I. M.;Mihretie E. T.;Minh L. H. N.;Mirfakhraie R.;Mirica A.;Mirrakhimov E. M.;Mirzaei M.;Misganaw A.;Misra S.;Mithra P.;Mizana B. A.;Mohamadkhani A.;Mohamed N. S.;Mohammadi E.;Mohammadi H.;Mohammadi S.;Mohammadi S.;Mohammadshahi M.;Mohammed M.;Mohammed S.;Mohammed S.;Mohan S.;Mojiri-Forushani H.;Moka N.;Mokdad A. H.;Molinaro S.;Moller H.;Monasta L.;Moniruzzaman M.;Montazeri F.;Moradi M.;Moradi Y.;Moradi-Lakeh M.;Moraga P.;Morovatdar N.;Morrison S. D.;Mosapour A.;Mosser J. F.;Mossialos E.;Motaghinejad M.;Mousavi P.;Ehsan Mousavi S.;Mubarik S.;Muccioli L.;Mughal F.;Mukoro G. D.;Mulita A.;Mulita F.;Musaigwa F.;Mustafa A.;Mustafa G.;Muthu S.;Nagarajan A. J.;Naghavi P.;Naik G. R.;Nainu F.;Nair T. S.;Najmuldeen H. H. 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A.;Pacheco-Barrios K.;Padubidri J. R.;Pal P. K.;Palange P. N.;Palladino C.;Palladino R.;Palma-Alvarez R. F.;Pan F.;Panagiotakos D.;Panda-Jonas S.;Pandey A.;Pandey A.;Pandian J. D.;Pangaribuan H. U.;Pantazopoulos I.;Pardhan S.;Parija P. P.;Parikh R. R.;Park S.;Parthasarathi A.;Pashaei A.;Patel J.;Patil S.;Patoulias D.;Pawar S.;Pedersini P.;Pensato U.;Pereira D. M.;Pereira J.;Pereira M. O.;Peres M. F. P.;Perico N.;Perna S.;Petcu I. -R.;Petermann-Rocha F. E.;Pham H. T.;Phillips M. R.;Pinilla-Monsalve G. D.;Piradov M. A.;Plotnikov E.;Poddighe D.;Polat B.;Poluru R.;Pond C. D.;Poudel G. R.;Pouramini A.;Pourbagher-Shahri A. M.;Pourfridoni M.;Pourtaheri N.;Prakash P. Y.;Prakash S.;Prakash V.;Prates E. J. S.;Pritchett N.;Purnobasuki H.;Qasim N. H.;Qattea I.;Qian G.;Radhakrishnan V.;Raee P.;Shahraki H. R.;Rafique I.;Raggi A.;Raghav P. R.;Rahati M. M.;Rahim F.;Rahimi Z.;Rahimifard M.;Rahman M. O.;Rahman M. H. U.;Rahman M.;Rahman M. A.;Rahmani A. M.;Rahmani S.;Youshanlouei H. R.;Rahmati M.;Raj Moolambally S.;Rajabpour-Sanati A.;Ramadan H.;Ramasamy S. K.;Ramasubramani P.;Ramazanu S.;Rancic N.;Rao I. R.;Rao S. J.;Rapaka D.;Rashedi V.;Rashid A. M.;Rashidi M. -M.;Rashidi Alavijeh M.;Rasouli-Saravani A.;Rawaf S.;Razo C.;Redwan E. M. M.;Bana A. R.;Remuzzi G.;Rezaei N.;Rezaei N.;Rezaei N.;Rezaeian M.;Rhee T. G.;Riad A.;Robinson S. R.;Rodrigues M.;Rodriguez J. A. B.;Roever L.;Rogowski E. L. B.;Romoli M.;Ronfani L.;Roy P.;Pramanik K. R.;Rubagotti E.;Ruiz M. A.;Russ T. C.;Sunnerhagen K. S.;Saad A. M. A.;Saadatian Z.;Saber K.;SaberiKamarposhti M.;Sacco S.;Saddik B.;Sadeghi E.;Sadeghian S.;Saeed U.;Saeed U.;Safdarian M.;Safi S. Z.;Sagar R.;Sagoe D.;Saheb Sharif-Askari F. S.;Saheb Sharif-Askari N.;Sahebkar A.;Sahoo S. S.;Sahraian M. A.;Sajedi S. A.;Sakshaug J. W.;Saleh M. A.;Salehi Omran H.;Salem M. R.;Salimi S.;Samadi Kafil H.;Samadzadeh S.;Samargandy S.;Samodra Y. L.;Samuel V. P.;Samy A. M.;Sanadgol N.;Sanjeev R. K.;Sanmarchi F.;Santomauro D. F.;Santri I. N.;Santric-Milicevic M. M.;Saravanan A.;Sarveazad A.;Satpathy M.;Saylan M.;Sayyah M.;Scarmeas N.;Schlaich M. P.;Schuermans A.;Schwarzinger M.;Schwebel D. C.;Selvaraj S.;Sendekie A. K.;Sengupta P.;Senthilkumaran S.;Serban D.;Sergindo M. T.;Sethi Y.;SeyedAlinaghi S.;Seylani A.;Shabani M.;Shabany M.;Shafie M.;Shahabi S.;Shahbandi A.;Shahid S.;Shahraki-Sanavi F.;Shahsavari H. R.;Shahwan M. J.;Shaikh M. A.;Shaji K. S.;Sham S.;Shama A. T. T.;Shamim M. A.;Shams-Beyranvand M.;Shamsi M. A.;Shanawaz M.;Sharath M.;Sharfaei S.;Sharifan A.;Sharma M.;Sharma R.;Shashamo B. B.;Shayan M.;Sheikhi R. A.;Shekhar S.;Shen J.;Shenoy S. M.;Shetty P. H.;Shiferaw D. S.;Shigematsu M.;Shiri R.;Shittu A.;Shivakumar K. M.;Shokri F.;Shool S.;Shorofi S. A.;Shrestha S.;Siankam Tankwanchi A. B.;Siddig E. E.;Sigfusdottir I. D.;Silva J. P.;Silva L. M. L. R.;Sinaei E.;Singh B. B.;Singh G.;Singh P.;Singh S.;Sirota S. B.;Sivakumar S.;Sohag A. A. M.;Solanki R.;Soleimani H.;Solikhah S.;Solomon Y.;Solomon Y.;Song S.;Song Y.;Sotoudeh H.;Spartalis M.;Stark B. A.;Starnes J. R.;Starodubova A. V.;Stein D. J.;Steiner T. J.;Stovner L. J.;Suleman M.;Abdulkader R. S.;Sultana A.;Sun J.;Sunkersing D.;Sunny A.;Susianti H.;Swain C. K.;Szeto M. D.;Tabares-Seisdedos R.;Tabatabaei S. M.;Tabatabai S.;Tabish M.;Taheri M.;Tahvildari A.;Tajbakhsh A.;Tampa M.;Lukenze Tamuzi J. J. L.;Tan K. -K.;Tang H.;Tareke M.;Tarigan I. U.;Tat N. Y.;Tat V. Y.;Tavakoli Oliaee R.;Tavangar S. M.;Tavasol A.;Tefera Y. M.;Tehrani-Banihashemi A.;Temesgen W. A.;Temsah M. -H.;Teramoto M.;Tesfaye A. H.;Tesfaye E. G.;Tesler R.;Thakali O.;Thangaraju P.;Thapa R.;Thapar R.;Thomas N. K.;Thrift A. G.;Ticoalu J. H. V.;Tillawi T.;Toghroli R.;Tonelli M.;Tovani-Palone M. R.;Traini E.;Tran N. M.;Tran N. -H.;Van Tran P.;Tromans S. J.;Truelsen T. C.;Truyen T. T. T. T.;Tsatsakis A.;Tsegay G. M.;Tsermpini E. E.;Tualeka A. R.;Tufa D. G.;Ubah C. S.;Udoakang A. 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Z.;Zangiabadian M.;Zarghami A.;Zastrozhin M. S.;Zeariya M. G. M.;Zegeye Z. B.;Zeukeng F.;Zhai C.;Zhang C.;Zhang H.;Zhang Y.;Zhang Z. -J.;Zhao H.;Zhao Y.;Zheng P.;Zhou H.;Zhu B.;Zhumagaliuly A.;Zielinska M.;Zikarg Y. T.;Zoladl M.;Murray C. J. L.;Ong K. L.;Feigin V. L.;Vos T.;Dua T.
2024
Abstract
Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods: We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. Findings: Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer. Interpretation: As the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed. Funding: Bill & Melinda Gates Foundation.
Steinmetz, J., Seeher, K., Schiess, N., Nichols, E., Cao, B., Servili, C., et al. (2024). Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. LANCET NEUROLOGY, 23(4), 344-381 [10.1016/S1474-4422(24)00038-3].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/511899
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 598/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
