An improved synthesis of the precursor acetic acid-piperidine-4-yl ester by acetylation of 4-hydroxypiperidine hydrochloride in anhydrous chloroform was developed. A procedure for fast evaluation and characterization of products originated by acetylation of the 4-piperidinol using LC-APCI/MS with an acetonitrile-water gradient method on a Merck Purosphere RP-18 column was also developed. The highly purified precursor allowed the production of [C-11]MP4A for PET studies of acethylcholine neurotransmission system. The tracer was produced with > 98% radiochemical purity, with yields ranging 20-60% (decay-corrected) from EOB. (c) 2005 Elsevier Ltd. All rights reserved.

Carpinelli, A., Magni, F., Cattaneo, A., Matarrese, M., Turolla, E., Todde, S., et al. (2006). Improved synthesis and radiolabeling of [C-11]MP4A, a suitable ligand for the investigation of the cholinergic system using PET. APPLIED RADIATION AND ISOTOPES, 64(2), 182-186 [10.1016/j.apradiso.2005.07.014].

Improved synthesis and radiolabeling of [C-11]MP4A, a suitable ligand for the investigation of the cholinergic system using PET

MAGNI, FULVIO;CATTANEO, ALICE SILVIA;TUROLLA, ELIA ANNA;TODDE, SERGIO CAMILLO;KIENLE, MARZIA DONATELLA;FAZIO, FERRUCCIO
2006

Abstract

An improved synthesis of the precursor acetic acid-piperidine-4-yl ester by acetylation of 4-hydroxypiperidine hydrochloride in anhydrous chloroform was developed. A procedure for fast evaluation and characterization of products originated by acetylation of the 4-piperidinol using LC-APCI/MS with an acetonitrile-water gradient method on a Merck Purosphere RP-18 column was also developed. The highly purified precursor allowed the production of [C-11]MP4A for PET studies of acethylcholine neurotransmission system. The tracer was produced with > 98% radiochemical purity, with yields ranging 20-60% (decay-corrected) from EOB. (c) 2005 Elsevier Ltd. All rights reserved.
Articolo in rivista - Articolo scientifico
[C-11]MP4A; positron emission tomography (PET); LC-APCI/MS; acetic acid-piperidine-4-yl ester; N-methyl-4-piperidyl acetate; C-11
English
2006
64
2
182
186
none
Carpinelli, A., Magni, F., Cattaneo, A., Matarrese, M., Turolla, E., Todde, S., et al. (2006). Improved synthesis and radiolabeling of [C-11]MP4A, a suitable ligand for the investigation of the cholinergic system using PET. APPLIED RADIATION AND ISOTOPES, 64(2), 182-186 [10.1016/j.apradiso.2005.07.014].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/5089
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