A small set of N-bridged 1-deoxynojirimycin dimers has been synthesized and evaluated as potential inhibitors of insect trehalase from midge larvae of C. riparius, porcine trehalase as the mammalian counterpart and α-amylase from human saliva. All the tested compounds (2-4) proved to be active (micromolar range activity) against insect trehalase, showing selectivity towards the insect glycosidase. No activity was observed against α-amylase.
Cipolla, L., Sgambato, A., Forcella, M., Fusi, P., Parenti, P., Cardona, F., et al. (2014). N-bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors. CARBOHYDRATE RESEARCH, 389, 46-49 [10.1016/j.carres.2013.12.025].
N-bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors
CIPOLLA, LAURA FRANCESCA;SGAMBATO, ANTONELLA;FORCELLA, MATILDE EMMA;FUSI, PAOLA ALESSANDRA;PARENTI, PAOLO;BINI, DAVIDE
2014
Abstract
A small set of N-bridged 1-deoxynojirimycin dimers has been synthesized and evaluated as potential inhibitors of insect trehalase from midge larvae of C. riparius, porcine trehalase as the mammalian counterpart and α-amylase from human saliva. All the tested compounds (2-4) proved to be active (micromolar range activity) against insect trehalase, showing selectivity towards the insect glycosidase. No activity was observed against α-amylase.
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