The present invention relates to a novel process for the preparation of 2,4,6-triiodoisophthalic bisamide derivatives, which are useful intermediates in the preparation of non-ionic X-ray contrast agents, starting from the corresponding acyl chloride intermediates which are amidated in a mixture of specific hydrotropic solvents in the presence of a low amount of water. In addition, the invention relates to the use of such hydrotropic solvents in the preparation of said 2,4,6-triiodoisophthalic bisamide intermediates to produce non-ionic X-ray contrast agents.

Lattuada, L., Beverina, L., Sassi, M., Mattiello, S., Papagni, A., Zucchi, A. (2022)Process for the preparation of 2,4,6-triiodoisophthalic bisamides. . Brevetto No. PCT/EP2022/086082.

Process for the preparation of 2,4,6-triiodoisophthalic bisamides

Beverina, Luca;Sassi Mauro;Mattiello, Sara;Papagni, Antonio;Zucchi, Anita.
2022

Abstract

The present invention relates to a novel process for the preparation of 2,4,6-triiodoisophthalic bisamide derivatives, which are useful intermediates in the preparation of non-ionic X-ray contrast agents, starting from the corresponding acyl chloride intermediates which are amidated in a mixture of specific hydrotropic solvents in the presence of a low amount of water. In addition, the invention relates to the use of such hydrotropic solvents in the preparation of said 2,4,6-triiodoisophthalic bisamide intermediates to produce non-ionic X-ray contrast agents.
hydrotropes, green chemistry, X-rays contrast media, Iopamidol
Chemistry, Metallurgy
English
Rilevanza internazionale
15-dic-2022
PCT/EP2022/086082
29-giu-2023
WO2023117667A1
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Lattuada, L., Beverina, L., Sassi, M., Mattiello, S., Papagni, A., Zucchi, A. (2022)Process for the preparation of 2,4,6-triiodoisophthalic bisamides. . Brevetto No. PCT/EP2022/086082.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/505459
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