One of the most problematic steps in iodinated contrast agents synthesis (dx.doi.org/10.1021/cr200358s), is the amidation reaction: currently performed in aprotic dipolar solvents (DMF, NMP, DMAc). These solvents are subjected to an increasing regulatory pressure due to safety and environmental concerns. Our innovative protocol enables the amidation reaction between the acyl chloride intermediate and lipophilized serinol in water, the green solvent for excellence, by employing micellar catalysis technology (doi.org/10.1021/acs.oprd.0c00303), avoiding the use of such toxic solvents altogether.

Zucchi, A., Mattiello, S., Maschio, R., Sassi, M., Lattuada, L., Beverina, L. (2022). Application of micellar catalysis for a greener synthesis of Iopamidol. Intervento presentato a: New trends in organic syntheis, Milan, Italy.

Application of micellar catalysis for a greener synthesis of Iopamidol

Zucchi, Anita;Mattiello, Sara;Sassi, Mauro;Beverina, Luca
2022

Abstract

One of the most problematic steps in iodinated contrast agents synthesis (dx.doi.org/10.1021/cr200358s), is the amidation reaction: currently performed in aprotic dipolar solvents (DMF, NMP, DMAc). These solvents are subjected to an increasing regulatory pressure due to safety and environmental concerns. Our innovative protocol enables the amidation reaction between the acyl chloride intermediate and lipophilized serinol in water, the green solvent for excellence, by employing micellar catalysis technology (doi.org/10.1021/acs.oprd.0c00303), avoiding the use of such toxic solvents altogether.
abstract + poster
Green Chemistry, Iopamidol, Micellar catalysis, X-Rays contrast media
English
New trends in organic syntheis
2022
2022
reserved
Zucchi, A., Mattiello, S., Maschio, R., Sassi, M., Lattuada, L., Beverina, L. (2022). Application of micellar catalysis for a greener synthesis of Iopamidol. Intervento presentato a: New trends in organic syntheis, Milan, Italy.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/505381
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