Aims: The aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label. Methods and results: Four independent laboratories tested a small number of diagnostic antibodies kept at +4°C for 12-26 years, and found them to work perfectly on routine histology sections. Conclusions: Diagnostic antibodies may have a workable half-life in excess of 10 years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.
Argentieri, M., Pilla, D., Vanzati, A., Lonardi, S., Facchetti, F., Doglioni, C., et al. (2013). Antibodies are forever: a study using 12-26-year-old expired antibodies. HISTOPATHOLOGY, 63(6), 869-876 [10.1111/his.12225].
Antibodies are forever: a study using 12-26-year-old expired antibodies
CATTORETTI, GIORGIO
2013
Abstract
Aims: The aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label. Methods and results: Four independent laboratories tested a small number of diagnostic antibodies kept at +4°C for 12-26 years, and found them to work perfectly on routine histology sections. Conclusions: Diagnostic antibodies may have a workable half-life in excess of 10 years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.
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