Blood acidification by lactic acid infusion converts bicarbonate to CO2. This effect can be exploited to increase the transmembrane PCO2 gradient of an extracorporeal membrane lung, resulting in a significant increase of extracorporeal CO2 removal. Lactic acid, however, is an energetic substrate and its metabolism might increase total body CO2 production (VCO2), limiting the potential beneficial effects of this technique. The aim of our study was to compare VCO2 during isocaloric infusion of lactic acid or glucose.

Zanella, A., Giani, M., Redaelli, S., Mangili, P., Scaravilli, V., Ormas, V., et al. (2013). Infusion of 2.5 meq/min of lactic acid minimally increases CO2 production compared to an isocaloric glucose infusion in healthy anesthetized, mechanically ventilated pigs. CRITICAL CARE, 17(6), R268 [10.1186/cc13098].

Infusion of 2.5 meq/min of lactic acid minimally increases CO2 production compared to an isocaloric glucose infusion in healthy anesthetized, mechanically ventilated pigs

ZANELLA, ALBERTO;GIANI, MARCO;MANGILI, PAOLO;SCARAVILLI, VITTORIO;ORMAS, VALENTINA;BELLANI, GIACOMO;PATRONITI, NICOLO' ANTONINO;PESENTI, ANTONIO MARIA
2013

Abstract

Blood acidification by lactic acid infusion converts bicarbonate to CO2. This effect can be exploited to increase the transmembrane PCO2 gradient of an extracorporeal membrane lung, resulting in a significant increase of extracorporeal CO2 removal. Lactic acid, however, is an energetic substrate and its metabolism might increase total body CO2 production (VCO2), limiting the potential beneficial effects of this technique. The aim of our study was to compare VCO2 during isocaloric infusion of lactic acid or glucose.
Articolo in rivista - Articolo scientifico
ECMO
English
2013
17
6
R268
none
Zanella, A., Giani, M., Redaelli, S., Mangili, P., Scaravilli, V., Ormas, V., et al. (2013). Infusion of 2.5 meq/min of lactic acid minimally increases CO2 production compared to an isocaloric glucose infusion in healthy anesthetized, mechanically ventilated pigs. CRITICAL CARE, 17(6), R268 [10.1186/cc13098].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/48820
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