Pseudomonas stutzeri OX1 is able to grow on o-xylene but is unable to grow on m-xylene and p-xylene, which are partially metabolized through the o-xylene degradative pathway leading to the formation of dimethylphenols toxic to OX1. P. stutzeri spontaneous mutants able to grow on m-xylene and p-xylene have been isolated. These mutants soon lose the ability to grow on o-xylene. Data from HPLC analyses and from induction studies suggest that in these mutants m-xylene and p-xylene could be metabolized through the oxidation of a methyl substituent. P. stutzeri chromosomal DNA is shown to share homology with pWW0 catabolic genes. In the mutant strains the region homologous to pWW0 upper pathway genes has undergone a genomic rearrangement. © 1993 Kluwer Academic Publishers.
Barbieri, P., Palladino, L., DI GENNARO, P., Galli, E. (1993). Alternative pathways for o-xylene or m-xylene and p-xylene degradation in a Pseudomonas stutzeri strain. BIODEGRADATION, 4(2), 71-80 [10.1007/BF00702323].
Alternative pathways for o-xylene or m-xylene and p-xylene degradation in a Pseudomonas stutzeri strain
DI GENNARO, PATRIZIA;
1993
Abstract
Pseudomonas stutzeri OX1 is able to grow on o-xylene but is unable to grow on m-xylene and p-xylene, which are partially metabolized through the o-xylene degradative pathway leading to the formation of dimethylphenols toxic to OX1. P. stutzeri spontaneous mutants able to grow on m-xylene and p-xylene have been isolated. These mutants soon lose the ability to grow on o-xylene. Data from HPLC analyses and from induction studies suggest that in these mutants m-xylene and p-xylene could be metabolized through the oxidation of a methyl substituent. P. stutzeri chromosomal DNA is shown to share homology with pWW0 catabolic genes. In the mutant strains the region homologous to pWW0 upper pathway genes has undergone a genomic rearrangement. © 1993 Kluwer Academic Publishers.
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