We report two cases of severe refractory progressive chronic graft- versus-host disease (cGvHD) which improved dramatically after extracorporeal photochemotherapy. This procedure, based on functional changes of lymphocytes induced by 8-methoxypsoralen and UVA administered to leukapheresis collections, could be a useful treatment for cGvHD, even after many years of unsuccessful immunosuppressive approaches.
Biagi, E., Perseghin, P., Buscemi, F., Dassi, M., Rovelli, A., Balduzzi, A. (2000). Effectiveness of extracorporeal photochemotherapy in treating long-term refractory chronic graft-versus-host disease. HAEMATOLOGICA, 85(3), 329-330.
Effectiveness of extracorporeal photochemotherapy in treating long-term refractory chronic graft-versus-host disease
BIAGI, ETTORE;Balduzzi, A.
2000
Abstract
We report two cases of severe refractory progressive chronic graft- versus-host disease (cGvHD) which improved dramatically after extracorporeal photochemotherapy. This procedure, based on functional changes of lymphocytes induced by 8-methoxypsoralen and UVA administered to leukapheresis collections, could be a useful treatment for cGvHD, even after many years of unsuccessful immunosuppressive approaches.
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