All bound up: A small variant of protein A (red; see picture) was used as a biotemplate for the synthesis and biofunctionalization of gold nanoparticles (AuNPs). These functionalized AuNPs were able to bind to antibodies (green blocks, trastuzumab; TZ) with a defined orientation, thus showing promise as bio-nanoparticle systems suitable for selective cell labeling by membrane-receptor-specific recognition.
Colombo, M., Mazzucchelli, S., Collico, V., Avvakumova, S., Pandolfi, L., Corsi, F., et al. (2012). Protein-Assisted One-Pot Synthesis and Biofunctionalization of Spherical Gold Nanoparticles for Selective Targeting of Cancer Cells. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 51(37), 9272-9275 [10.1002/anie.201204699].
Protein-Assisted One-Pot Synthesis and Biofunctionalization of Spherical Gold Nanoparticles for Selective Targeting of Cancer Cells
COLOMBO, MIRIAM;MAZZUCCHELLI, SERENA;COLLICO, VERONICA;PANDOLFI, LAURA;PROSPERI, DAVIDE
2012
Abstract
All bound up: A small variant of protein A (red; see picture) was used as a biotemplate for the synthesis and biofunctionalization of gold nanoparticles (AuNPs). These functionalized AuNPs were able to bind to antibodies (green blocks, trastuzumab; TZ) with a defined orientation, thus showing promise as bio-nanoparticle systems suitable for selective cell labeling by membrane-receptor-specific recognition.
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