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The research project is focused on the development and the synthesis of glycoderivatives as potential drug candidates, for therapeutic use, and as molecular tools, for the study of biological processes. The project includes the study of SGLT1 (Sodium-Glucose co-transporter 1), its role in inflammatory processes and the development of potential carbohydrate-based anti-inflammatory agents. Furthermore, new glycoderivatives and glycoconjugates will be synthetized for other potential pharmacological applications such as the targeting of cytotoxic drugs, as novel potential anticancer agents, and for the development of molecular tools to study several biological phenomena.

(2013). Glycoderivatives: drug candidates and molecular tools. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2013).

Glycoderivatives: drug candidates and molecular tools

D'ORAZIO, GIUSEPPE
2013

Abstract

The research project is focused on the development and the synthesis of glycoderivatives as potential drug candidates, for therapeutic use, and as molecular tools, for the study of biological processes. The project includes the study of SGLT1 (Sodium-Glucose co-transporter 1), its role in inflammatory processes and the development of potential carbohydrate-based anti-inflammatory agents. Furthermore, new glycoderivatives and glycoconjugates will be synthetized for other potential pharmacological applications such as the targeting of cytotoxic drugs, as novel potential anticancer agents, and for the development of molecular tools to study several biological phenomena.
LA FERLA, BARBARA
glycoderivatives, molecular tools, C-glycosides, carbohydrate chemistry, anti-inflammatory molecules, glycosidases, radiolabeling, multivalency, gold nanoparticles, iminosugars, calixarenes, arsenic, cancer.
CHIM/06 - CHIMICA ORGANICA
English
6-feb-2013
BIOTECNOLOGIE INDUSTRIALI - 15R
25
2011/2012
The research work presented in this manuscript is a result of collaborations between the research group in which I worked, supervised by Dr. Barbara La Ferla, PhD and Prof. Francesco Nicotra, and several Italian and European coworkers. Chapter 2 and chapter 3 describe a research project in collaboration with the research group of Prof. Cristiano Rumio (University of Milan – Humanitas Clinical Institute (Milan)). An acknowledgment goes to Dr. Diego Cardani which performed the biological experiments. In chapter 4 is described a research work carried out in collaboration with the research group of Prof. Soledad Penàdes (Laboratory of Biofunctional Nanomaterials – CicbiomaGUNE, Donostia – San Sebastiàn, Basque Contry, Spain). In particular, the preparation of the gold nanoparticles was carried out during an one month research period in this research center, under the supervision of Dr. Marco Marradi, PhD.. My research period abroad was carried out within the COST Network project (COST Action CM1102). Chapter 5 is a result of a collaboration with the research group of Prof. Alessandro Dondoni (University of Ferrara, Italy) and Prof. Alberto Marra (University of Montpellier 2, France). In particular, their work was focused on the preparation of the calixarene structures and their functionalization with the prepared iminosugars. Chapter 6 presents a work performed in collaboration with Prof. Marco Salvetti research group (University of Rome – La Sapienza) and Dr. Michele Pitaro (Xenuspharma s.r.l, Rome).
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(2013). Glycoderivatives: drug candidates and molecular tools. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2013).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/41154
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