The aim of the study is to evaluate the effectiveness of short whole-body magnetic resonance imaging (WBMRI) protocols for the overall assessment of bone marrow involvement in patients with multiple myeloma (MM), in comparison with standard whole-body MRI protocol. Patients with biopsy-proven MM, who underwent a WBMRI with full-body coverage (from vertex to feet) were retrospectively enrolled. WBMRI images were independently evaluated by two expert radiologists, in terms of infiltration patterns (normal, focal, diffuse, and combined), according to location (the whole skeleton was divided into six anatomic districts: skull, spine, sternum and ribs, upper limbs, pelvis and proximal two-thirds of the femur, remaining parts of lower limbs) and lytic lesions number ([removed]20). The majority of patients showed focal and combined infiltration patterns with bone lesions predominantly distributed in the spine and pelvis. As skull and lower limbs are less frequently involved by focal bone lesions, excluding them from the standard MRI protocol allows to obtain a shorter protocol, maintaining a good diagnostic value.

Ippolito, D., Giandola, T., Maino, C., Gandola, D., Ragusi, M., Brambilla, P., et al. (2021). Diagnostic value of whole-body mri short protocols in bone lesion detection in multiple myeloma patients. DIAGNOSTICS, 11(6) [10.3390/diagnostics11061053].

Diagnostic value of whole-body mri short protocols in bone lesion detection in multiple myeloma patients

Ippolito D.
;
Giandola T.;Gandola D.;Ragusi M.;Brambilla P.;Bonaffini P. A.;Sironi S.
2021

Abstract

The aim of the study is to evaluate the effectiveness of short whole-body magnetic resonance imaging (WBMRI) protocols for the overall assessment of bone marrow involvement in patients with multiple myeloma (MM), in comparison with standard whole-body MRI protocol. Patients with biopsy-proven MM, who underwent a WBMRI with full-body coverage (from vertex to feet) were retrospectively enrolled. WBMRI images were independently evaluated by two expert radiologists, in terms of infiltration patterns (normal, focal, diffuse, and combined), according to location (the whole skeleton was divided into six anatomic districts: skull, spine, sternum and ribs, upper limbs, pelvis and proximal two-thirds of the femur, remaining parts of lower limbs) and lytic lesions number ([removed]20). The majority of patients showed focal and combined infiltration patterns with bone lesions predominantly distributed in the spine and pelvis. As skull and lower limbs are less frequently involved by focal bone lesions, excluding them from the standard MRI protocol allows to obtain a shorter protocol, maintaining a good diagnostic value.
Articolo in rivista - Articolo scientifico
Diffusion-weighted imaging; Hematologic neoplasms; Infiltration pattern; Magnetic resonance imaging; Multiple myeloma;
English
2021
11
6
1053
open
Ippolito, D., Giandola, T., Maino, C., Gandola, D., Ragusi, M., Brambilla, P., et al. (2021). Diagnostic value of whole-body mri short protocols in bone lesion detection in multiple myeloma patients. DIAGNOSTICS, 11(6) [10.3390/diagnostics11061053].
File in questo prodotto:
File Dimensione Formato  
10281-402987_VoR.pdf

accesso aperto

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Licenza: Creative Commons
Dimensione 15.81 MB
Formato Adobe PDF
15.81 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/402987
Citazioni
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
Social impact