PerioGlas (R) is a synthetic absorbable osteoconductive bone graft substitute composed of a calcium phosphosilicate bioactive glass. To evaluate its effect on Adipose Drived Stem Cells colture, a gene expression analysis was carried out by using Reverse Transcriptase Polymerase Chain Reaction. The up-regulation of SPP1, FOSL1 and RUNX2, demonstrated that PerioGlas promotes osteoblast differentiation in ADSCs and is actively resorbed by human osteoclasts. For these reasons it could be used as scaffold in bone tissue engineering.
Brunelli, G., Carinci, F., Girardi, A., Palmieri, A., Caccianiga, G., Sollazzo, V. (2012). PERIOGLASS (R) AND ITS OSTEOGENIC POTENTIAL. EUROPEAN JOURNAL OF INFLAMMATION, 10(1), 43-47.
PERIOGLASS (R) AND ITS OSTEOGENIC POTENTIAL
Caccianiga, GianluigiCo-ultimo
;
2012
Abstract
PerioGlas (R) is a synthetic absorbable osteoconductive bone graft substitute composed of a calcium phosphosilicate bioactive glass. To evaluate its effect on Adipose Drived Stem Cells colture, a gene expression analysis was carried out by using Reverse Transcriptase Polymerase Chain Reaction. The up-regulation of SPP1, FOSL1 and RUNX2, demonstrated that PerioGlas promotes osteoblast differentiation in ADSCs and is actively resorbed by human osteoclasts. For these reasons it could be used as scaffold in bone tissue engineering.
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