ALGIPORE (R) STIMULATES OSTEBLAST DIFFERENTIATION IN ADIPOSE DERIVED STEM CELLS

Advances in bone grafting are progressing with the evolution of biomaterials that permit the incorporation of osteoinductive and osteogenic proteins into osteoconductive composite scaffolds. Algipore (R), a hydroxyapatite ceramic obtained from red alga, is largely employed as scaffolds in bone regeneration. For this reason, we studied if and how Algipore (R) can induce osteoblast differentiation in stem cells derived from adipose tissue, measuring the expression levels of bone related genes and mesenchymal stem cells marker by real time RT-PCR. The obtained results demonstrated that Algipore (R) enhances differentiation and deposition of matrix in stem cells by the activation of osteoblast and related genes FOSL1, COL1A1, SPP1, SP7 and ALPL.