Background and Objective: Interleukin 10 (IL-10) has been shown to be elevated in the plasma of cancer-bearing patients. The source of systemic IL- 10 may be the tumor microenvironment. We therefore tried to evaluate if ablative surgery for gastrointestinal cancer could affect the levels of circulating IL-10. Methods: Plasma IL-10 concentration was measured in 45 patients with adenocarcinoma of the gastrointestinal tract. Forty healthy subjects, 15 women undergoing hysterectomy for uterine fibroma, and 15 patients undergoing palliative operation for pancreatic cancer were used as control groups. Plasma IL-10 was assessed I day before surgery (baseline) and 1, 4, and 8 days after operation. Results: The baseline concentration of IL- 10 was significantly higher in cancer patients than in healthy subjects and in women with fibroma (8.6 ng/mL, 2.1 and 1.8 respectively; P = 0.015). After radical surgery, the IL-10 levels significantly dropped in cancer patients (from 8.6 ng/mL to 3.8; P = 0...
Gianotti, L., Fortis, C., Braga, M., Gentilini, O., Vignali, A., Di Carlo, V. (1997). Radical oncologic surgery affects the circulatory levels of interleukin 10. JOURNAL OF SURGICAL ONCOLOGY, 66(4), 244-247 [10.1002/(SICI)1096-9098(199712)66:4<244::AID-JSO4>3.0.CO;2-B].
Radical oncologic surgery affects the circulatory levels of interleukin 10
GIANOTTI, LUCA VITTORIO;Braga, M;
1997
Abstract
Background and Objective: Interleukin 10 (IL-10) has been shown to be elevated in the plasma of cancer-bearing patients. The source of systemic IL- 10 may be the tumor microenvironment. We therefore tried to evaluate if ablative surgery for gastrointestinal cancer could affect the levels of circulating IL-10. Methods: Plasma IL-10 concentration was measured in 45 patients with adenocarcinoma of the gastrointestinal tract. Forty healthy subjects, 15 women undergoing hysterectomy for uterine fibroma, and 15 patients undergoing palliative operation for pancreatic cancer were used as control groups. Plasma IL-10 was assessed I day before surgery (baseline) and 1, 4, and 8 days after operation. Results: The baseline concentration of IL- 10 was significantly higher in cancer patients than in healthy subjects and in women with fibroma (8.6 ng/mL, 2.1 and 1.8 respectively; P = 0.015). After radical surgery, the IL-10 levels significantly dropped in cancer patients (from 8.6 ng/mL to 3.8; P = 0...
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