(2R)-2-Amino-8-methoxy-1,2,3,4-tetrahydronaphthalene, a useful precursor of the 5-hydroxytryptamine receptor agonist 8-OH-DPAT((2R)-2-(dipropylamino)-8-hydroxytetrahydronaphthalene), has been synthesized from 1-methoxynaphthalene through a chemoenzymatic protocol. The same protocol has been subsequently applied to the synthesis of other (2R)-2-amino-1,2,3,4-tetrahydronaphthalenes. (C) 2002 Published by Elsevier Science Ltd.
Orsini, F., Sello, G., Travaini, E., DI GENNARO, P. (2002). A chemoenzymatic synthesis of (2R)-8-substituted-2-aminotetralins. TETRAHEDRON-ASYMMETRY, 13(3), 253-259 [10.1016/S0957-4166(02)00098-8].
A chemoenzymatic synthesis of (2R)-8-substituted-2-aminotetralins
DI GENNARO, PATRIZIA
2002
Abstract
(2R)-2-Amino-8-methoxy-1,2,3,4-tetrahydronaphthalene, a useful precursor of the 5-hydroxytryptamine receptor agonist 8-OH-DPAT((2R)-2-(dipropylamino)-8-hydroxytetrahydronaphthalene), has been synthesized from 1-methoxynaphthalene through a chemoenzymatic protocol. The same protocol has been subsequently applied to the synthesis of other (2R)-2-amino-1,2,3,4-tetrahydronaphthalenes. (C) 2002 Published by Elsevier Science Ltd.
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