(1) Background: Anaemia is a common finding in patients with colon cancer and is commonly corrected by blood transfusion prior to surgery. However, the prognostic role of perioperative transfusions is still debated. The aim of the present study was to investigate the role of preoperative anaemia and preoperative blood transfusion in influencing the prognosis in colon cancer. (2) Patients and Methods: Patients undergoing elective surgery for colon cancer at a tertiary referral university hospital between January 2010 and December 2018 were included in a retrospective review of a prospectively collected database. Univariate and regression analyses were performed to identify the prognostic role of preoperative anaemia and preoperative transfusions in this homogeneous cohort of patients. (3) Results: A total of 780 patients were included in the final analysis. The estimated five-year overall survival rate was significantly worse in the anaemic group (83.8% in non-anaemic patients, 60.6% in mild anaemic patients, 61.3% in moderate anaemic patients and 58.4% in severe anaemic patients; log-rank < 0.001 vs. non-anaemic patients). Anaemic status was found to be an independent adverse prognostic factor (hazard ratio (HR): 1.46; 95% confidence interval (CI): 1.02–2.07) during multivariate analysis. Among moderate to severe anaemic patients, no significant association was found between preoperative transfusions and the risk of mortality or recurrence. (4) Conclusions: Preoperative anaemia, regardless of its severity, and not preoperative blood transfu-sion, was independently associated with a worse prognosis after surgery in patients with colonic cancer.

Tamini, N., Gianotti, L., Darwish, S., Petitto, S., Bernasconi, D., Oldani, M., et al. (2021). Do preoperative transfusions impact prognosis in moderate to severe anaemic surgical patients with colon cancer?. CURRENT ONCOLOGY, 28(6), 4634-4644 [10.3390/curroncol28060391].

Do preoperative transfusions impact prognosis in moderate to severe anaemic surgical patients with colon cancer?

Tamini N.
;
Gianotti L.;Darwish S.;Petitto S.;Bernasconi D.;Oldani M.;Uggeri F.;Braga M.;Nespoli L.
2021

Abstract

(1) Background: Anaemia is a common finding in patients with colon cancer and is commonly corrected by blood transfusion prior to surgery. However, the prognostic role of perioperative transfusions is still debated. The aim of the present study was to investigate the role of preoperative anaemia and preoperative blood transfusion in influencing the prognosis in colon cancer. (2) Patients and Methods: Patients undergoing elective surgery for colon cancer at a tertiary referral university hospital between January 2010 and December 2018 were included in a retrospective review of a prospectively collected database. Univariate and regression analyses were performed to identify the prognostic role of preoperative anaemia and preoperative transfusions in this homogeneous cohort of patients. (3) Results: A total of 780 patients were included in the final analysis. The estimated five-year overall survival rate was significantly worse in the anaemic group (83.8% in non-anaemic patients, 60.6% in mild anaemic patients, 61.3% in moderate anaemic patients and 58.4% in severe anaemic patients; log-rank < 0.001 vs. non-anaemic patients). Anaemic status was found to be an independent adverse prognostic factor (hazard ratio (HR): 1.46; 95% confidence interval (CI): 1.02–2.07) during multivariate analysis. Among moderate to severe anaemic patients, no significant association was found between preoperative transfusions and the risk of mortality or recurrence. (4) Conclusions: Preoperative anaemia, regardless of its severity, and not preoperative blood transfu-sion, was independently associated with a worse prognosis after surgery in patients with colonic cancer.
Articolo in rivista - Articolo scientifico
anaemia; Blood transfusion; Colon cancer; Colon surgery; Oncologic outcomes;
English
12-nov-2021
2021
28
6
4634
4644
open
Tamini, N., Gianotti, L., Darwish, S., Petitto, S., Bernasconi, D., Oldani, M., et al. (2021). Do preoperative transfusions impact prognosis in moderate to severe anaemic surgical patients with colon cancer?. CURRENT ONCOLOGY, 28(6), 4634-4644 [10.3390/curroncol28060391].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/337638
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