In biological processes, intrinsic noise, spatial heterogeneity and molecular crowding deeply affect the system dynamics. The classic stochastic methods lack of the necessary features needed for the description of these phenomena. Membrane systems are a suitable framework to embed these characteristics; in particular, the variants of τ-DPP and Sτ -DPP allow the modelling and stochastic simulations of multi-volume biochemical systems, in which diffusion and size of volumes and chemicals are taken into account improving the description of these biological systems. In this paper we show, by means of two models of reaction-diffusion and crowded systems, the correctness and accuracy of our simulation methods.

Mosca, E., Cazzaniga, P., Pescini, D., Mauri, G., Milanesi, L. (2010). Modelling spatial heterogeneity and macromolecular crowding with membrane systems. In Proc. CMC11 – 11th Intern. Conf. on Membrane Computing (pp.285-304). Berlin : Springer [10.1007/978-3-642-18123-8_23].

Modelling spatial heterogeneity and macromolecular crowding with membrane systems

PESCINI, DARIO;MAURI, GIANCARLO;
2010

Abstract

In biological processes, intrinsic noise, spatial heterogeneity and molecular crowding deeply affect the system dynamics. The classic stochastic methods lack of the necessary features needed for the description of these phenomena. Membrane systems are a suitable framework to embed these characteristics; in particular, the variants of τ-DPP and Sτ -DPP allow the modelling and stochastic simulations of multi-volume biochemical systems, in which diffusion and size of volumes and chemicals are taken into account improving the description of these biological systems. In this paper we show, by means of two models of reaction-diffusion and crowded systems, the correctness and accuracy of our simulation methods.
slide + paper
stochastic simulation; Membrane systems
English
11th Intern. Conf. on Membrane Computing
2010
Proc. CMC11 – 11th Intern. Conf. on Membrane Computing
978-3-642-18122-1
2010
LNCS 6501
285
304
none
Mosca, E., Cazzaniga, P., Pescini, D., Mauri, G., Milanesi, L. (2010). Modelling spatial heterogeneity and macromolecular crowding with membrane systems. In Proc. CMC11 – 11th Intern. Conf. on Membrane Computing (pp.285-304). Berlin : Springer [10.1007/978-3-642-18123-8_23].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/32379
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