Magnetic Resonance Imaging (MRI) using paramagnetic systems as contrast agents is receiving increased attention as diagnostic tool in the clinic. At the same time, NMR of paramagnetic systems can also be applied in biochemical fields; for example, the use of Paramagnetic Relaxation Enhancement (PRE) allows structure refinement and the analysis of transient dynamic processes involved in macromolecular complex formation. Herein we report the synthesis and computational characterization of a new DOTA-like sialic acid conjugate, which can be used both in MRI and PRE applications when coordinated to a suitable paramagnetic metal. (C) 2012 Elsevier Ltd. All rights reserved.
Bini, D., Gregori, M., Cosentino, U., Moro, G., Canales, A., Capitoli, A., et al. (2012). Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications. CARBOHYDRATE RESEARCH, 354, 21-31 [10.1016/j.carres.2012.03.002].
Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications
BINI, DAVIDE;GREGORI, MARIA;COSENTINO, UGO RENATO;MORO, GIORGIO;CAPITOLI, ALICE;CIPOLLA, LAURA FRANCESCA
2012
Abstract
Magnetic Resonance Imaging (MRI) using paramagnetic systems as contrast agents is receiving increased attention as diagnostic tool in the clinic. At the same time, NMR of paramagnetic systems can also be applied in biochemical fields; for example, the use of Paramagnetic Relaxation Enhancement (PRE) allows structure refinement and the analysis of transient dynamic processes involved in macromolecular complex formation. Herein we report the synthesis and computational characterization of a new DOTA-like sialic acid conjugate, which can be used both in MRI and PRE applications when coordinated to a suitable paramagnetic metal. (C) 2012 Elsevier Ltd. All rights reserved.
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