Starting from the early 2000s, paired associative stimulation (PAS) protocols have been used in humans to study brain connectivity in motor and sensory networks by exploiting the intrinsic properties of timing-dependent cortical plasticity. In the last 10 years, PAS have also been developed to investigate the plastic properties of complex cerebral systems, such as the frontal ones, with promising results. In the present work, we review the most recent advances of this technique, focusing on protocols targeting frontal cortices to investigate connectivity and its plastic properties, subtending high-order cognitive functions like memory, decision-making, attentional, or emotional processing. Overall, current evidence reveals that PAS can be effectively used to assess, enhance or depress physiological connectivity within frontal networks in a timing-dependent way, in turn modulating cognitive processing in healthy and pathological conditions.

Guidali, G., Roncoroni, C., Bolognini, N. (2021). Modulating Frontal Networks’ Timing-Dependent-Like Plasticity With Paired Associative Stimulation Protocols: Recent Advances and Future Perspectives. FRONTIERS IN HUMAN NEUROSCIENCE, 15(22 April 2021) [10.3389/fnhum.2021.658723].

Modulating Frontal Networks’ Timing-Dependent-Like Plasticity With Paired Associative Stimulation Protocols: Recent Advances and Future Perspectives

Guidali, Giacomo
Primo
;
Bolognini, Nadia
Ultimo
2021

Abstract

Starting from the early 2000s, paired associative stimulation (PAS) protocols have been used in humans to study brain connectivity in motor and sensory networks by exploiting the intrinsic properties of timing-dependent cortical plasticity. In the last 10 years, PAS have also been developed to investigate the plastic properties of complex cerebral systems, such as the frontal ones, with promising results. In the present work, we review the most recent advances of this technique, focusing on protocols targeting frontal cortices to investigate connectivity and its plastic properties, subtending high-order cognitive functions like memory, decision-making, attentional, or emotional processing. Overall, current evidence reveals that PAS can be effectively used to assess, enhance or depress physiological connectivity within frontal networks in a timing-dependent way, in turn modulating cognitive processing in healthy and pathological conditions.
Articolo in rivista - Articolo scientifico
executive functions; frontal cortex; fronto-parietal (executive) network; paired associative stimulation; spike-timing-dependent plasticity; transcranial magnetic stimulation;
English
2021
15
22 April 2021
658723
open
Guidali, G., Roncoroni, C., Bolognini, N. (2021). Modulating Frontal Networks’ Timing-Dependent-Like Plasticity With Paired Associative Stimulation Protocols: Recent Advances and Future Perspectives. FRONTIERS IN HUMAN NEUROSCIENCE, 15(22 April 2021) [10.3389/fnhum.2021.658723].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/312631
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