Recently we showed that Ethanolamine Kinase 1 (ETNK1) mutations cause a decreased synthesis of phosphoethanolamine, and that phosphoethanolamine is able to modulate mitochondrial activity through competition with succinate for complex II. The decreased phosphoethanolamine concentration leads to increased mitochondria activity and reactive oxygen species production, which causes the accumulation of new mutations.

Fontana, D., Gambacorti Passerini, C., Piazza, R. (2021). Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage. MOLECULAR & CELLULAR ONCOLOGY, 8(2) [10.1080/23723556.2021.1877598].

Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage

Fontana, D;Gambacorti Passerini, C;Piazza, R
2021

Abstract

Recently we showed that Ethanolamine Kinase 1 (ETNK1) mutations cause a decreased synthesis of phosphoethanolamine, and that phosphoethanolamine is able to modulate mitochondrial activity through competition with succinate for complex II. The decreased phosphoethanolamine concentration leads to increased mitochondria activity and reactive oxygen species production, which causes the accumulation of new mutations.
Articolo in rivista - Articolo scientifico
DNA damage; ETNK1; mitochondria; phosphoethanolamine; reactive oxigen species;
English
19-feb-2021
2021
8
2
1877598
none
Fontana, D., Gambacorti Passerini, C., Piazza, R. (2021). Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage. MOLECULAR & CELLULAR ONCOLOGY, 8(2) [10.1080/23723556.2021.1877598].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/308503
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