Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. Findings: Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973–0.988, p < 0.001) and per increase in ambient temperature of 1°C to be 0.854 (0.773–0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. Interpretation: Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation.

Kifer, D., Bugada, D., Villar-Garcia, J., Gudelj, I., Menni, C., Sudre, C., et al. (2021). Effects of Environmental Factors on Severity and Mortality of COVID-19. FRONTIERS IN MEDICINE, 7 [10.3389/fmed.2020.607786].

Effects of Environmental Factors on Severity and Mortality of COVID-19

Menni C.;Lorini L. F.;Maloberti A.;Giannattasio C.;Rossetti C.;
2021

Abstract

Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. Findings: Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973–0.988, p < 0.001) and per increase in ambient temperature of 1°C to be 0.854 (0.773–0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. Interpretation: Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation.
Articolo in rivista - Articolo scientifico
COVID-19; humidity; mortality; mucins; seasonality;
English
20-gen-2021
2021
7
607786
open
Kifer, D., Bugada, D., Villar-Garcia, J., Gudelj, I., Menni, C., Sudre, C., et al. (2021). Effects of Environmental Factors on Severity and Mortality of COVID-19. FRONTIERS IN MEDICINE, 7 [10.3389/fmed.2020.607786].
File in questo prodotto:
File Dimensione Formato  
10281-306807_VoR.pdf

accesso aperto

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Licenza: Creative Commons
Dimensione 1.2 MB
Formato Adobe PDF
1.2 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/306807
Citazioni
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 33
Social impact