The first use of a two-level approach that combines Self-Organizing Maps (SOMs) and hierarchical clustering for the comparison of protein dynamics is presented. The method was developed and tested on the SH3 domain and a group of its mutants and successfully recovered information about the differences in the domain flexibilities that affect their biological function. The approach was then extended to other study cases to analyse the role of conformational flexibility in modulating the domain functions.
Fraccalvieri, D., Stella, F., Pandini, A., Bonati, L. (2011). A new methodology for the comparison of protein dynamics based on self-organizing maps. In Proceedings.
A new methodology for the comparison of protein dynamics based on self-organizing maps
FRACCALVIERI, DOMENICO;STELLA, FABIO ANTONIO;BONATI, LAURA
2011
Abstract
The first use of a two-level approach that combines Self-Organizing Maps (SOMs) and hierarchical clustering for the comparison of protein dynamics is presented. The method was developed and tested on the SH3 domain and a group of its mutants and successfully recovered information about the differences in the domain flexibilities that affect their biological function. The approach was then extended to other study cases to analyse the role of conformational flexibility in modulating the domain functions.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
