Osteoplant® is an equine cortical and spongy bone tissue, used to fill bone defects in orthopedic, maxillofacial and dental surgery. To study the mechanism by which Osteoplant® induce the reabsorption and the substitution of the graft with new bone, the expression of genes related to the osteoblast differentiation were analyzed using cultures of stem cells derived from adipose tissue treated with Osteoplant®. Gene expression profile, obtained with real time Reverse Transcription-Polymerase Chain Reaction demonstrated that Osteoplant® influences the differentiation of adipose derived stem cells by the activation of bone related genes like osteopontin (SPP1) and alkaline phosphatase (ALPL)
Brunelli, G., Sollazzo, V., Carinci, F., Palmieri, A., Girardi, A., Monguzzi, R. (2011). Osteoplant modulates genes expression in adipose derived stem cells during osteoblast differentiation. EUROPEAN JOURNAL OF INFLAMMATION, 9(suppl 3), 109-113.
Osteoplant modulates genes expression in adipose derived stem cells during osteoblast differentiation
Monguzzi, R
2011
Abstract
Osteoplant® is an equine cortical and spongy bone tissue, used to fill bone defects in orthopedic, maxillofacial and dental surgery. To study the mechanism by which Osteoplant® induce the reabsorption and the substitution of the graft with new bone, the expression of genes related to the osteoblast differentiation were analyzed using cultures of stem cells derived from adipose tissue treated with Osteoplant®. Gene expression profile, obtained with real time Reverse Transcription-Polymerase Chain Reaction demonstrated that Osteoplant® influences the differentiation of adipose derived stem cells by the activation of bone related genes like osteopontin (SPP1) and alkaline phosphatase (ALPL)
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