The past few years observed a breakthrough of genome sequences of bacteria of Rhodococcus genus with significant biodegradation abilities. Invaluable knowledge from genome data and their functional analysis can be applied to develop and design strategies for attenuating damages caused by hydrocarbon contamination. With the advent of high-throughput -omic technologies, it is currently possible to utilize the functional properties of diverse catabolic genes, analyze an entire system at the level of molecule (DNA, RNA, protein, and metabolite), simultaneously predict and construct catabolic degradation pathways. In this review, the genes involved in the biodegradation of hydrocarbons and several emerging plasticizer compounds in Rhodococcus strains are described in detail (aliphatic, aromatics, PAH, phthalate, polyethylene, and polyisoprene). The metabolic biodegradation networks predicted from omics-derived data along with the catabolic enzymes exploited in diverse biotechnological and bioremediation applications are characterized.

Zampolli, J., Zeaiter, Z., Di Canito, A., Di Gennaro, P. (2019). Genome analysis and -omics approaches provide new insights into the biodegradation potential of Rhodococcus. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 103(3), 1069-1080 [10.1007/s00253-018-9539-7].

Genome analysis and -omics approaches provide new insights into the biodegradation potential of Rhodococcus

Zampolli J.;Zeaiter Z.;Di Canito A.;Di Gennaro P.
2019

Abstract

The past few years observed a breakthrough of genome sequences of bacteria of Rhodococcus genus with significant biodegradation abilities. Invaluable knowledge from genome data and their functional analysis can be applied to develop and design strategies for attenuating damages caused by hydrocarbon contamination. With the advent of high-throughput -omic technologies, it is currently possible to utilize the functional properties of diverse catabolic genes, analyze an entire system at the level of molecule (DNA, RNA, protein, and metabolite), simultaneously predict and construct catabolic degradation pathways. In this review, the genes involved in the biodegradation of hydrocarbons and several emerging plasticizer compounds in Rhodococcus strains are described in detail (aliphatic, aromatics, PAH, phthalate, polyethylene, and polyisoprene). The metabolic biodegradation networks predicted from omics-derived data along with the catabolic enzymes exploited in diverse biotechnological and bioremediation applications are characterized.
Articolo in rivista - Review Essay
-omics; Biodegradation; Gene cluster; Recalcitrant compounds; Rhodococcus;
-omics; Biodegradation; Gene cluster; Recalcitrant compounds; Rhodococcus; Bacterial Proteins; Environmental Pollutants; Genome, Bacterial; Hydrocarbons, Aromatic; Metabolic Networks and Pathways
English
2019
103
3
1069
1080
reserved
Zampolli, J., Zeaiter, Z., Di Canito, A., Di Gennaro, P. (2019). Genome analysis and -omics approaches provide new insights into the biodegradation potential of Rhodococcus. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 103(3), 1069-1080 [10.1007/s00253-018-9539-7].
File in questo prodotto:
File Dimensione Formato  
REVIEW-RHODOCOCCUS.pdf

Solo gestori archivio

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 725.83 kB
Formato Adobe PDF
725.83 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/282627
Citazioni
  • Scopus 61
  • ???jsp.display-item.citation.isi??? 48
Social impact