Leucoencefalopatia in soggetto con artrite reumatoide in trattamento con metotrexato a basso dosaggio: complicanza prevedibile o eccezionale ed in attesa?

The Authors describe the story of a patient with rheumatoid arthritis being treated with weekly intramuscular low dose methotrexate, who developed a multifocal leukoencephalopathy, with significant neurological syndrome. The complication was related to drug administration only belatedly, which was suspended with stabilization of the clinical picture. Literature was reviewed.