Luong-Gardiol et al. show that Wnt pathway activity mediated by γ-catenin is critical for BCR-ABL1 + B-ALL, in contrast to β-catenin being important in CML. B-ALL is more sensitive to partial reduction of MYC expression level than CML, and γ-catenin regulates the expression of MYC and Survivin in B-ALL.
Luong-Gardiol, N., Siddiqui, I., Pizzitola, I., Jeevan-Raj, B., Charmoy, M., Huang, Y., et al. (2019). γ-Catenin-Dependent Signals Maintain BCR-ABL1 + B Cell Acute Lymphoblastic Leukemia. CANCER CELL, 35(4), 649-663.e10 [10.1016/j.ccell.2019.03.005].
γ-Catenin-Dependent Signals Maintain BCR-ABL1 + B Cell Acute Lymphoblastic Leukemia
Pizzitola I.;Cazzaniga G.;
2019
Abstract
Luong-Gardiol et al. show that Wnt pathway activity mediated by γ-catenin is critical for BCR-ABL1 + B-ALL, in contrast to β-catenin being important in CML. B-ALL is more sensitive to partial reduction of MYC expression level than CML, and γ-catenin regulates the expression of MYC and Survivin in B-ALL.
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