Come dansyl with me! A small library of naphthyl gluco derivatives was synthesised from methyl α-D-glucopyranoside without protection/ deprotection steps. One library member, dansyl C-glucoside 5, showed an extraordinary anti-inflammatory activity, protecting 100□% of mice from sepsis at a dose of 25 μg□kg-1.

LA FERLA, B., Spinosa, V., D'Orazio, G., Palazzo, M., Balsari, A., Foppoli, A., et al. (2010). Dansyl C-Glucoside as a novel agent against endotoxic shock. CHEMMEDCHEM, 5(10), 1677-1680 [10.1002/cmdc.201000282].

Dansyl C-Glucoside as a novel agent against endotoxic shock

LA FERLA, BARBARA;D'ORAZIO, GIUSEPPE;NICOTRA, FRANCESCO
2010

Abstract

Come dansyl with me! A small library of naphthyl gluco derivatives was synthesised from methyl α-D-glucopyranoside without protection/ deprotection steps. One library member, dansyl C-glucoside 5, showed an extraordinary anti-inflammatory activity, protecting 100□% of mice from sepsis at a dose of 25 μg□kg-1.
Articolo in rivista - Articolo scientifico
Glycomimetics, C-Glycosides, Chemoselectivity, Sepsis, Endotoxic shock
English
2010
5
10
1677
1680
none
LA FERLA, B., Spinosa, V., D'Orazio, G., Palazzo, M., Balsari, A., Foppoli, A., et al. (2010). Dansyl C-Glucoside as a novel agent against endotoxic shock. CHEMMEDCHEM, 5(10), 1677-1680 [10.1002/cmdc.201000282].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/21000
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