Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases. © 2011 The Royal Society of Chemistry.

Rizzi, L., Braschi, M., Colombo, M., Vaiana, N., Tibolla, G., Norata, G., et al. (2011). Novel Biotinylated Bile Acid Amphiphiles: Micellar Aggregates Formation and Interaction with Hepatocytes. ORGANIC & BIOMOLECULAR CHEMISTRY, 9(8), 2899-2905 [10.1039/C0OB00878H].

Novel Biotinylated Bile Acid Amphiphiles: Micellar Aggregates Formation and Interaction with Hepatocytes

Colombo, M;PROSPERI, DAVIDE
2011

Abstract

Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases. © 2011 The Royal Society of Chemistry.
Articolo in rivista - Articolo scientifico
micelle; nanobiotecnologie; avidina-biotina; bioconiugazione
English
2011
9
8
2899
2905
none
Rizzi, L., Braschi, M., Colombo, M., Vaiana, N., Tibolla, G., Norata, G., et al. (2011). Novel Biotinylated Bile Acid Amphiphiles: Micellar Aggregates Formation and Interaction with Hepatocytes. ORGANIC & BIOMOLECULAR CHEMISTRY, 9(8), 2899-2905 [10.1039/C0OB00878H].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/20557
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