Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.

Taylor, S., Hardwick, K., Sawin, K., Biggins, S., Piatti, S., Khodjakov, A., et al. (2007). Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". SCIENCE, 316(5827), 982-982 [10.1126/science.1139484].

Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint"

PIATTI, SIMONETTA;
2007

Abstract

Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.
Articolo in rivista - Articolo scientifico
spindle assembly checkpoint; centrosome
English
18-mag-2007
316
5827
982
982
none
Taylor, S., Hardwick, K., Sawin, K., Biggins, S., Piatti, S., Khodjakov, A., et al. (2007). Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". SCIENCE, 316(5827), 982-982 [10.1126/science.1139484].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/2018
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