A set of poly(lactic-co-glycolic acid) polymers functionalized with different monosaccharides as well as glycodendrimers and surface-decorated nanoparticles (NPs) were synthesized and characterized. The functionalization of the polymer was carried out through amide bond formation with amino-modified sugar monomers and through a biocompatible chemoselective method exploiting the reducing end of a free sugar. The assemblage of the NPs adopting a nanoprecipitation method was straightforward and allowed the preparation of sugars/sugar dendrimer coated NPs
Palmioli, A., La Ferla, B. (2018). Glycofunctionalization of Poly(lactic-co-glycolic acid) Polymers: Building Blocks for the Generation of Defined Sugar-Coated Nanoparticles. ORGANIC LETTERS, 20(12), 3509-3512 [10.1021/acs.orglett.8b01287].
Glycofunctionalization of Poly(lactic-co-glycolic acid) Polymers: Building Blocks for the Generation of Defined Sugar-Coated Nanoparticles
Palmioli, A;La Ferla, B
2018
Abstract
A set of poly(lactic-co-glycolic acid) polymers functionalized with different monosaccharides as well as glycodendrimers and surface-decorated nanoparticles (NPs) were synthesized and characterized. The functionalization of the polymer was carried out through amide bond formation with amino-modified sugar monomers and through a biocompatible chemoselective method exploiting the reducing end of a free sugar. The assemblage of the NPs adopting a nanoprecipitation method was straightforward and allowed the preparation of sugars/sugar dendrimer coated NPs
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