The PhD thesis is focused on the evaluation of different Mass Spectrometry approaches for the study of the proteome of biological fluids and tissues. In detail, the ClinProt technology has been applied to amniotic fluids and urines respectively, to evaluate potential biomarkers for the preterm premature rupture of the membranes (pPROM) and to invetsigate molecular mechanisms of kidney adaptation to hypobaric hypoxia conditions at high and very high altitude. MALDI Imaging Mass Spectrometry (IMS) has been applied for the study of tissues. In detail, this part of the work evaluated the use of the detergents to enhance sensitivity and number of peaks detected for protein IMS analysis.
(2011). Indagini molecolari mediante spettrometrial di massa in fluidi biologici e tessuti. (Tesi di dottorato, Università degli Studi di Milano-Bicocca, 2011).
Indagini molecolari mediante spettrometrial di massa in fluidi biologici e tessuti
MAININI, VERONICA
2011
Abstract
The PhD thesis is focused on the evaluation of different Mass Spectrometry approaches for the study of the proteome of biological fluids and tissues. In detail, the ClinProt technology has been applied to amniotic fluids and urines respectively, to evaluate potential biomarkers for the preterm premature rupture of the membranes (pPROM) and to invetsigate molecular mechanisms of kidney adaptation to hypobaric hypoxia conditions at high and very high altitude. MALDI Imaging Mass Spectrometry (IMS) has been applied for the study of tissues. In detail, this part of the work evaluated the use of the detergents to enhance sensitivity and number of peaks detected for protein IMS analysis.
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Phd_unimib_070410.pdf
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