Taking its toll: LPS-coated magnetic nanoparticles (LMNPs) are synthesized by noncovalently linking LPS to oleylamine-coated iron oxide nanoparticles. LMNPs are stable, water-soluble, have homogeneous size and shape, and load an average of 130 LPS molecules. LMNPs induce mild CD14-dependent Toll-like receptor 4 (TLR4) activation in innate immune cells (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Piazza, M., Colombo, M., Zanoni, I., Granucci, F., Tortora, P., Weiss, J., et al. (2011). Uniform Lipopolysaccharide (LPS)-Loaded Magnetic Nanoparticles for the Investigation of LPS–TLR4 Signaling. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 50(3), 622-626 [10.1002/anie.201004655].
Uniform Lipopolysaccharide (LPS)-Loaded Magnetic Nanoparticles for the Investigation of LPS–TLR4 Signaling
PIAZZA, MATTEO;COLOMBO, MIRIAM;ZANONI, IVAN;GRANUCCI, FRANCESCA;TORTORA, PAOLO;PROSPERI, DAVIDE;PERI, FRANCESCO
2011
Abstract
Taking its toll: LPS-coated magnetic nanoparticles (LMNPs) are synthesized by noncovalently linking LPS to oleylamine-coated iron oxide nanoparticles. LMNPs are stable, water-soluble, have homogeneous size and shape, and load an average of 130 LPS molecules. LMNPs induce mild CD14-dependent Toll-like receptor 4 (TLR4) activation in innate immune cells (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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