We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.
Perani, D., Garibotto, V., Panzacchi, A., Moresco, R., Ortelli, P., Corbo, M., et al. (2007). PET evidence of central GABAergic changes in stiff person syndrome. MOVEMENT DISORDERS, 22(7), 1030-1033 [10.1002/mds.21441].
PET evidence of central GABAergic changes in stiff person syndrome
MORESCO, ROSA MARIA;FAZIO, FERRUCCIO;
2007
Abstract
We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.
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