The procedure previously reported for the radiosynthesis of [123I]betaCIT was modified in order to improve both radiochemical yield and purity of betaCIT (2beta-carbomethoxy-3beta(4-iodophenyl) tropane) to be injected for SPECT (Single Photon Emission Computed Tomography) analysis imaging. The overall procedure, involving a HPLC purification step, results in quite good and reproducible yields of a highly purified tracer.
Carpinelli, A., Matarrese, M., Moresco, R., Simonelli, P., Todde, S., Magni, F., et al. (2001). Radiosynthesis of [123I]βCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain. APPLIED RADIATION AND ISOTOPES, 54(1), 93-95 [10.1016/S0969-8043(00)00179-2].
Radiosynthesis of [123I]βCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain
MORESCO, ROSA MARIA;TODDE, SERGIO CAMILLO;MAGNI, FULVIO;KIENLE, MARZIA DONATELLA;FAZIO, FERRUCCIO
2001
Abstract
The procedure previously reported for the radiosynthesis of [123I]betaCIT was modified in order to improve both radiochemical yield and purity of betaCIT (2beta-carbomethoxy-3beta(4-iodophenyl) tropane) to be injected for SPECT (Single Photon Emission Computed Tomography) analysis imaging. The overall procedure, involving a HPLC purification step, results in quite good and reproducible yields of a highly purified tracer.
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