Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS
Ferrarese, C., Sala, G., Riva, R., Begni, B., Zoia, C., Tremolizzo, L., et al. (2001). Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis. NEUROLOGY, 56(2), 270-272 [10.1212/WNL.56.2.270].
Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis
Ferrarese, C;Sala, G;Zoia, CP;Tremolizzo, L;Galimberti, G;
2001
Abstract
Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS
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