Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localization of mRNAs. This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs. The interplay between miRNAs and RBPs is discussed specifically in the context of neuronal development and function.

Loffreda, A., Rigamonti, A., Barabino, S., Lenzken, S. (2015). RNA-binding proteins in the regulation of miRNA activity: A focus on neuronal functions. BIOMOLECULES, 5(4), 2363-2387 [10.3390/biom5042363].

RNA-binding proteins in the regulation of miRNA activity: A focus on neuronal functions

Loffreda, A;Rigamonti, A;Barabino, S;Lenzken, S
2015

Abstract

Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localization of mRNAs. This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs. The interplay between miRNAs and RBPs is discussed specifically in the context of neuronal development and function.
Articolo in rivista - Review Essay
MiRNA; MiRNA-RBP competition; MiRNA-RBP cooperation; Neuronal-gene-expression-regulation; RBPs; RNA binding proteins;
English
30-set-2015
2015
5
4
2363
2387
A08
partially_open
Loffreda, A., Rigamonti, A., Barabino, S., Lenzken, S. (2015). RNA-binding proteins in the regulation of miRNA activity: A focus on neuronal functions. BIOMOLECULES, 5(4), 2363-2387 [10.3390/biom5042363].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/107064
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